Long‐term clinical outcome in meige syndrome treated with internal pallidum deep brain stimulation
Identifieur interne : 001583 ( Main/Exploration ); précédent : 001582; suivant : 001584Long‐term clinical outcome in meige syndrome treated with internal pallidum deep brain stimulation
Auteurs : René Reese [Allemagne] ; Doreen Gruber [Allemagne] ; Thomas Schoenecker [Allemagne] ; Hansjörg B Zner [Allemagne] ; Christian Blahak [Allemagne] ; H. Holger Capelle [Allemagne] ; Daniela Falk [Allemagne] ; Jan Herzog [Allemagne] ; Marcus O. Pinsker [Allemagne] ; Gerd H. Schneider [Allemagne] ; Christoph Schrader [Allemagne] ; Günther Deuschl [Allemagne] ; Günther M. Mehdorn [Allemagne] ; Andreas Kupsch [Allemagne] ; Jens Volkmann [Allemagne] ; Joachim K. Krauss [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-03.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Analysis of Variance, Deep Brain Stimulation (methods), Deep brain stimulation, Dystonia, Electrodes, Female, Globus Pallidus (physiology), Humans, Long term, Longitudinal Studies, Male, Meige Syndrome (physiopathology), Meige Syndrome (therapy), Meige syndrome, Middle Aged, Motor Activity (physiology), Nervous system diseases, Pallidum, Prognosis, Severity of Illness Index, Treatment, Treatment Outcome, deep brain stimulation, dystonia, globus pallidus.
- MESH :
- methods : Deep Brain Stimulation.
- physiology : Globus Pallidus, Motor Activity.
- physiopathology : Meige Syndrome.
- therapy : Meige Syndrome.
- Aged, Analysis of Variance, Electrodes, Female, Humans, Longitudinal Studies, Male, Middle Aged, Severity of Illness Index, Treatment Outcome.
Abstract
Deep brain stimulation of the globus pallidus internus (GPi DBS) is effective in the treatment of primary segmental and generalized dystonia. Although limb, neck, or truncal dystonia are markedly improved, orofacial dystonia is ameliorated to a lesser extent. Nevertheless, several case reports and small cohort studies have described favorable short‐term results of GPi DBS in patients with severe Meige syndrome. Here, we extend this preliminary experience by reporting long‐term outcome in a multicenter case series, following 12 patients (6 women, 6 men) with Meige syndrome for up to 78 months after bilateral GPi DBS. We retrospectively assessed dystonia severity based on preoperative and postoperative video documentation. Mean age of patients at surgery was 64.5 ± 4.4 years, and mean disease duration 8.3 ± 4.4 years. Dystonia severity as assessed by the Burke–Fahn–Marsden Dystonia Rating Scale showed a mean improvement of 45% at short‐term follow‐up (4.4 ± 1.5 months; P < 0.001) and of 53% at long‐term follow‐up (38.8 ± 21.7 months; P < 0.001). Subscores for eyes were improved by 38% (P = 0.004) and 47% (P < 0.001), for mouth by 50% (P < 0.001) and 56% (P < 0.001), and for speech/swallowing by 44% (P = 0.058) and 64% (P = 0.004). Mean improvements were 25% (P = 0.006) and 38% (P < 0.001) on the Blepharospasm Movement Scale and 44% (P < 0.001) and 49% (P < 0.001) on the Abnormal Involuntary Movement Scale. This series, which is the first to demonstrate a long‐term follow‐up in a large number of patients, shows that GPi DBS is a safe and highly effective therapy for Meige syndrome. The benefit is preserved for up to 6 years. © 2011 Movement Disorder Society
Url:
DOI: 10.1002/mds.23549
Affiliations:
- Allemagne
- Bade-Wurtemberg, Basse-Saxe, Berlin, District de Karlsruhe, Schleswig-Holstein
- Berlin, Hanovre, Kiel, Mannheim
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Krauss</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurosurgery, Hannover Medical School, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-03">2011-03</date><biblScope unit="vol">26</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="691">691</biblScope><biblScope unit="page" to="698">698</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">498EB25D68DB3B02951D5E9ADAAFEBAB64C3E7E4</idno><idno type="DOI">10.1002/mds.23549</idno><idno type="ArticleID">MDS23549</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Deep Brain Stimulation (methods)</term><term>Deep brain stimulation</term><term>Dystonia</term><term>Electrodes</term><term>Female</term><term>Globus Pallidus (physiology)</term><term>Humans</term><term>Long term</term><term>Longitudinal Studies</term><term>Male</term><term>Meige Syndrome (physiopathology)</term><term>Meige Syndrome (therapy)</term><term>Meige syndrome</term><term>Middle Aged</term><term>Motor Activity (physiology)</term><term>Nervous system diseases</term><term>Pallidum</term><term>Prognosis</term><term>Severity of Illness Index</term><term>Treatment</term><term>Treatment Outcome</term><term>deep brain stimulation</term><term>dystonia</term><term>globus pallidus</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Globus Pallidus</term><term>Motor Activity</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Meige Syndrome</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Meige Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Electrodes</term><term>Female</term><term>Humans</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Severity of Illness Index</term><term>Treatment Outcome</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Dystonie</term><term>Long terme</term><term>Pallidum</term><term>Pathologie du système nerveux</term><term>Pronostic</term><term>Stimulation cérébrale profonde</term><term>Syndrome de Meige</term><term>Traitement</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Deep brain stimulation of the globus pallidus internus (GPi DBS) is effective in the treatment of primary segmental and generalized dystonia. Although limb, neck, or truncal dystonia are markedly improved, orofacial dystonia is ameliorated to a lesser extent. Nevertheless, several case reports and small cohort studies have described favorable short‐term results of GPi DBS in patients with severe Meige syndrome. Here, we extend this preliminary experience by reporting long‐term outcome in a multicenter case series, following 12 patients (6 women, 6 men) with Meige syndrome for up to 78 months after bilateral GPi DBS. We retrospectively assessed dystonia severity based on preoperative and postoperative video documentation. Mean age of patients at surgery was 64.5 ± 4.4 years, and mean disease duration 8.3 ± 4.4 years. Dystonia severity as assessed by the Burke–Fahn–Marsden Dystonia Rating Scale showed a mean improvement of 45% at short‐term follow‐up (4.4 ± 1.5 months; P < 0.001) and of 53% at long‐term follow‐up (38.8 ± 21.7 months; P < 0.001). Subscores for eyes were improved by 38% (P = 0.004) and 47% (P < 0.001), for mouth by 50% (P < 0.001) and 56% (P < 0.001), and for speech/swallowing by 44% (P = 0.058) and 64% (P = 0.004). Mean improvements were 25% (P = 0.006) and 38% (P < 0.001) on the Blepharospasm Movement Scale and 44% (P < 0.001) and 49% (P < 0.001) on the Abnormal Involuntary Movement Scale. This series, which is the first to demonstrate a long‐term follow‐up in a large number of patients, shows that GPi DBS is a safe and highly effective therapy for Meige syndrome. The benefit is preserved for up to 6 years. © 2011 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bade-Wurtemberg</li><li>Basse-Saxe</li><li>Berlin</li><li>District de Karlsruhe</li><li>Schleswig-Holstein</li></region><settlement><li>Berlin</li><li>Hanovre</li><li>Kiel</li><li>Mannheim</li></settlement></list><tree><country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Reese, Rene" sort="Reese, Rene" uniqKey="Reese R" first="René" last="Reese">René Reese</name></region><name sortKey="B Zner, Hansjorg" sort="B Zner, Hansjorg" uniqKey="B Zner H" first="Hansjörg" last="B Zner">Hansjörg B Zner</name><name sortKey="Blahak, Christian" sort="Blahak, Christian" uniqKey="Blahak C" first="Christian" last="Blahak">Christian Blahak</name><name sortKey="Capelle, H Holger" sort="Capelle, H Holger" uniqKey="Capelle H" first="H. Holger" last="Capelle">H. Holger Capelle</name><name sortKey="Deuschl, Gunther" sort="Deuschl, Gunther" uniqKey="Deuschl G" first="Günther" last="Deuschl">Günther Deuschl</name><name sortKey="Falk, Daniela" sort="Falk, Daniela" uniqKey="Falk D" first="Daniela" last="Falk">Daniela Falk</name><name sortKey="Gruber, Doreen" sort="Gruber, Doreen" uniqKey="Gruber D" first="Doreen" last="Gruber">Doreen Gruber</name><name sortKey="Herzog, Jan" sort="Herzog, Jan" uniqKey="Herzog J" first="Jan" last="Herzog">Jan Herzog</name><name sortKey="Krauss, Joachim K" sort="Krauss, Joachim K" uniqKey="Krauss J" first="Joachim K." last="Krauss">Joachim K. Krauss</name><name sortKey="Kupsch, Andreas" sort="Kupsch, Andreas" uniqKey="Kupsch A" first="Andreas" last="Kupsch">Andreas Kupsch</name><name sortKey="Mehdorn, Gunther M" sort="Mehdorn, Gunther M" uniqKey="Mehdorn G" first="Günther M." last="Mehdorn">Günther M. Mehdorn</name><name sortKey="Pinsker, Marcus O" sort="Pinsker, Marcus O" uniqKey="Pinsker M" first="Marcus O." last="Pinsker">Marcus O. Pinsker</name><name sortKey="Pinsker, Marcus O" sort="Pinsker, Marcus O" uniqKey="Pinsker M" first="Marcus O." last="Pinsker">Marcus O. Pinsker</name><name sortKey="Schneider, Gerd H" sort="Schneider, Gerd H" uniqKey="Schneider G" first="Gerd H." last="Schneider">Gerd H. Schneider</name><name sortKey="Schoenecker, Thomas" sort="Schoenecker, Thomas" uniqKey="Schoenecker T" first="Thomas" last="Schoenecker">Thomas Schoenecker</name><name sortKey="Schrader, Christoph" sort="Schrader, Christoph" uniqKey="Schrader C" first="Christoph" last="Schrader">Christoph Schrader</name><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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